Disease-information

The efficacy and safety of Dydrogesterone for treatment of Dysmenorrhea
Dysmenorrhea, or menstrual pain, is the most common menstrual symptom among adolescent girls and young women. Most adolescents experiencing dysmenorrhea have primary dysmenorrhea, defined as painful menstruation in the absence of pelvic pathology. Primary dysmenorrhea characteristically begins when adolescents attain ovulatory cycles, usually w...
Blood pressure-lowering treatment for prevention of major CVD’S in people with and without Type 2 diabetes
The LANCET: Diabetes & Endocrinology: Published on July, 2022Diabetes is a major cause of death, cardiovascular complications, and health-care burden worldwide.People with type 2 diabetes who have high blood pressure are at an increased risk of morbidity and death from major cardiovascular events.However, there are inadequate randomised contro...
Blood pressure-lowering treatment for prevention of major CVD’S in people with and without Type 2 diabetes
The LANCET: Diabetes & Endocrinology: Published on July, 2022Diabetes is a major cause of death, cardiovascular complications, and health-care burden worldwide.People with type 2 diabetes who have high blood pressure are at an increased risk of morbidity and death from major cardiovascular events.However, there are inadequate randomised contro...
Levetiracetam versus Phenobarbitone in Neonatal Seizures
Seizures are the most common manifestation of neurological insult during the neonatal period. The most common cause of symptomatic neonatal seizures is hypoxic/ischemic encephalopathy (HIE) which affects approximately 1-2/100 live births.There are no evidence-based guidelines for the pharmacologic treatment of neonatal seizures and management...
Montelukast and Budesonide combination for children with Chronic Cough-Variant Asthma
Chronic cough-variant asthma (CCVA) is a very common subtype of bronchial asthma among children population. This condition often manifests with acute cough, chronic cough, and intractable cough, especially at night. It has been reported that CCVA contributed 24.0% to 33.3% of chronic cough cases, and children alone accounted for the incidence o...
Montelukast and Budesonide combination for children with Chronic Cough-Variant Asthma
Chronic cough-variant asthma (CCVA) is a very common subtype of bronchial asthma among children population. This condition often manifests with acute cough, chronic cough, and intractable cough, especially at night. It has been reported that CCVA contributed 24.0% to 33.3% of chronic cough cases, and children alone accounted for the incidence o...
Sequential treatment with Empagliflozin and Linagliptin is an effective treatment option in people with type 2 diabetes receiving Metformin
Diabetes, Obesity and Metabolism Journal: PubMedTAKE HOME MESSAGE:The study aims to investigate the effect of sequential treatment escalation with empagliflozin and linagliptin on laboratory markers of α- and β-cell function in people with type 2 diabetes mellitus (T2DM) insufficiently controlled on metformin monotherapy.The researchers found t...
Reductions in endometriosis-associated pain in women treated with Elagolix are consistent in various demographics or medical histories
Endometriosis can be asymptomatic; women often experience a range of symptoms with dysmenorrhea, non-menstrual pelvic pain (NMPP), and dyspareunia being more common; other symptoms include constipation, dyschezia, dysuria, and infertility. For many women, the burden of symptoms associated with endometriosis also reduces quality of life and profound...
Levetiracetam, Fosphenytoin, and Valproate for Status Epilepticus patients who do not respond to Benzodiazepines
The New England Journal of Medicine: Published on December, 2019Evidence supports the use of benzodiazepines as the initial treatment for status epilepticus; however, seizures do not respond to benzodiazepines in up to a third of patients. Of the three medications most commonly used to treat benzodiazepine-refractory status epilepticus — leveti...
Treatment for Mild Chronic Hypertension during Pregnancy
The New England Journal of Medicine (NEJM): Published on April, 2022Antihypertensive treatment during pregnancy reduces the frequency of severe hypertension (blood pressure, ≥160/110 mm Hg) but has not been shown to improve maternal, fetal, or neonatal outcomes and has been associated with an increased risk of small-for-gestational-age birth w...
Treatment for Mild Chronic Hypertension during Pregnancy
The New England Journal of Medicine (NEJM): Published on April, 2022Antihypertensive treatment during pregnancy reduces the frequency of severe hypertension (blood pressure, ≥160/110 mm Hg) but has not been shown to improve maternal, fetal, or neonatal outcomes and has been associated with an increased risk of small-for-gestational-age birth w...
Diagnosis and Management of Hand Foot and Mouth Disease (HFMD)
Hand-foot-and-mouth disease (HFMD) is a common but highly contagious acute viral infection due to an enterovirus infection. The disease is most common under the age of 10, and most are under 5 years of age (95%). It can uncommonly affect adults and tends to be more severe in the elderly, immunocompromised, and pregnant women.  What is the cause...